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扫描电镜与药物研发息息相关

 发布时间:2019-10-22 点击量:218

SUIZHEDAQIWURANHEQICHEWEIQIDAILAIDEXIAOCHUANHEMANXINGZUSAIXINGFEIBING(COPD)HUANZHEDERIYIZENGDUO,XIRUSHIGANFENZHIJI(Dry Powder Inhalation,DPI)DEYANFAHEFANGZHIYINGLAILEJIYU。

 

滚球体育XIRUGANFENZHIJI(Dry Powder Inhalation,DPI)YOUCHENGWEIGANFENXIRUJI,SHIZHIJIANGHUOXINGYAOWUCHENGFEN(Active Pharmaceutical Ingredient, API)YIGANFENDEXINGSHITONGGUOHUXIDAOXIRU,ZUOYONGYUHUXIDAONIANMOHEFEIPAODEYIZHONGJIYAOFANGSHI。YUKOUFUJIXINGXIANGBI,XIRUSHIGANFENZHIJIZHIJIEZUOYONGYUHUXIDAOHEFEIPAO,JUYOUYONGLIANGSHAO、QIXIAOKUAI、FUZUOYONGDIDENGMINGXIANYOUSHI。

 

“粒度分布可视为不同 DPI 配方中一个重要的设计因素。” (A.J. HICKEY) 

 

滚球体育GANFENXIRUJIDEXIRUXINGNENGYU API DEGUANJIANZHILIANGSHUXING(CQA)YANGEXIANGGUAN,TONGCHANG API DELIJINGYAOQIUFANWEIWEI 1-5μm。LIJINGDAYU 10μm DEKELIZAIXIRUGUOCHENG,KENENGCHONGJIHOUBUBIBINGQIETONGCHANGDAODABULEFEIBU;LIJING 2-5μm DEKELITONGCHANGCHENJIZAIXIZHIQIGUANZHONG,ERLIJINGFANWEI 50nm-3μm DEKELICAIHUICHENJIZAIFEIPAOZHONGBINGQIEBEIXUEYEXISHOU。CHULEXIDUYAOQIUGAO、HAIXUYAOFEICHANGZHAIDELIJINGFENBU。FEINADIANJINGYUKELITONGJIXITONGWEICITIGONGLELIANGHAODECESHISHOUDUAN。



滚球体育扫描电镜有着所见即所得的优势,可以很直观的对颗粒的粒径分布及均匀性进行定性与评估。

 

滚球体育DANSHIJINJINTONGGUOSAOMIAODIANJINGTUPIANWUFADUIFENTIZHENGTIQINGKUANGJINXINGPINGJIA。WEILEJIEJUEZHEIGENANTI,FEINADIANJINGCAIQUZIDONGQUTUGONGZUOFANGSHI,PEIHEKELISHIBIEXITONG,KEYIDUIFENTICAILIAOZHENGTIQINGKUANGDUOGEWEIDUJINXINGZHUNQUEDINGLIANGTONGJI,QIZHONGBAOKUOKELILIJING,YUANDU,ZONGHENGBI,AOTUDU。

 

 滚球体育  

 

滚球体育GENJUCESHITONGJIJIEGUOFENXI,CIPICI API FENMO D90 = 5.49 WEIMI,YIWEIZHE 90% DEKELIXIAOYU 5.49 WEIMI,SHIJIYINGYONGGUOCHENGZHONG,SUIZHEXIRU,API FENMOKEYIDAODAXIZHIQIGUANNAIZHIFEIPAOWEIZHI,YOUHENDAJIHUIFAHUIYAOWUZUOYONG。

 

ZUOWEIKELICHICUNDECELIANGSHOUDUAN,SAOMIAODIANJINGZAIYANZHENGQITACHANGGUIKELICHICUNCEDINGJISHU(LIRUJIGUANGLIDUYIHUODONGTAIGUANGSANSHE)DEKEKAOXINGFANGMIANYEQIZHEZHONGYAOZUOYONG。

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